Health & Fitness

Can COVID-19 Symptoms Come Back After Using Paxlovid? What We Know

  • Some individuals who have taken Pfizer Inc.’s COVID-19 antiviral report that their signs return after finishing the 5-day remedy.
  • In Pfizer’s scientific trial, 1 to 2 p.c of individuals handled with the antiviral nonetheless examined constructive for COVID after ending the remedy.
  • Specialists say that whereas these instances have to be studied, Paxlovid remains to be a key remedy for COVID-19.

Some sufferers who’ve taken Pfizer Inc.’s oral antiviral Paxlovid are reporting that their COVID-19 signs returned after initially bettering after they accomplished remedy.

Right here’s what we all know thus far about this rebounding of signs.

To date, just one case has shown up in the medical literature as a pre-print.

On this report, the affected person’s signs cleared up after which returned a few week after remedy. This coincided with a rise within the quantity of virus in his physique or viral load.

Different individuals have posted about their rebounding signs on social media or reported them to the Meals and Drug Administration.

At the moment, this kind of rebounding seems to be uncommon.

In Pfizer’s scientific trial, 1 to 2 percent of people handled with the antiviral had a constructive COVID-19 check — or a rise within the quantity of virus detected — after ending the remedy.

Nevertheless, this kind of rebound additionally occurred in individuals who acquired the inactive placebo, so it’s not clear whether it is associated to the drug, said the FDA.

As well as, the company stated that individuals within the trial whose signs recurred didn’t have a better threat of hospitalization or dying. Nor had been there indicators that the coronavirus had developed resistance to the drug.

It’s not clear why some individuals see a recurrence of their signs. However U.S. authorities researchers are already planning studies on this.

Specialists say that whereas these instances of rebound have to be studied, this shouldn’t be seen as a failure of Paxlovid.

Within the Pfizer clinical trial, the antiviral lowered the chance of COVID-19-related hospitalization and dying by virtually 90 p.c amongst non-hospitalized sufferers liable to extreme sickness.

Dr. Jeffrey Klausner, a scientific professor within the Keck College of Drugs of the College of Southern California, stated Paxlovid is a “life-saver” — reducing the quantity of virus current within the physique, decreasing signs, and stopping sickness from getting worse.

“The remedy works exceptionally effectively at stopping individuals in danger — [such as] aged, overweight or these with different medical circumstances like diabetes or hypertension — from ending up the hospital,” stated Klausner.

“That’s what’s necessary — stopping individuals from going to the hospital,” he added.

Whereas some scientists have urged {that a} 10-day course of Paxlovid could also be wanted, the FDA stated proper now there is no such thing as a proof {that a} longer course of pills presents additional benefit.

Dr. John Mourani, medical director of infectious illness at Pomona Valley Hospital Medical Center, stated if signs recur, “the very first thing sufferers ought to do is contact their major doctor for a COVID antigen examine.”

They’ll additionally use an at-home check package. Some medical doctors recommend having these available in case you are taking Paxlovid.

Scientists don’t know whether or not all individuals whose signs recur can unfold the virus to others, however they advocate taking steps to guard others from an infection.

“If signs return after remedy, there’s a chance that somebody should be contagious,” stated Klausner. “Folks ought to proceed isolating and sporting a masks till their signs are gone, or till they check destructive on a fast check.”

In america, Paxlovid is authorized by the FDA to be used in individuals 12 years and older who’ve examined constructive for coronavirus an infection and are at excessive threat for extreme sickness.

Folks at greater threat embody these with risk factors similar to continual lung or kidney illness, diabetes, weight problems, most cancers, or any situation that weakens their immune system.

Each vaccinated, and unvaccinated persons are eligible to obtain Paxlovid. Nevertheless, vaccination offers an added layer of safety.

“General, having the vaccine and therapeutic choices together are useful gizmo to guard from extreme COVID,” stated Mourani.

A prescription is required for the antiviral drugs, and remedy must be began inside 5 days of the signs beginning.

To get a prescription, you will have to point out your constructive check end result to your well being supplier and evaluation your threat elements. Some telehealth suppliers additionally supply digital visits to evaluate your threat and prescribe Paxlovid whether it is applicable.

It’s also possible to go to one of many test to treat locations supported by the federal authorities. These websites supply testing and have Paxlovid on-hand.

In late April, the White Home made a brand new push to get Paxlovid to Individuals who may benefit.

Regardless of this, Klausner is anxious that these most in danger are nonetheless not conscious of this remedy and usually are not getting handled.

“Now we have to do a significantly better job selling the remedy to at-risk individuals and making it simpler to get,” he stated.

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